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Invitrogen
RNaseL Polyclonal Antibody
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RNaseL Antibody (PA5-119400) in IHC (P)
Immunohistochemistry (Paraffin) analysis of RNaseL in human stomach cancer tissue using RNaseL Polyclonal Antibody (Product # PA5-119400) (30 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Rabbit IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
产品信息
PA5-119400
产品规格
种属反应
Human,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Ribonuclease L. The antigen corresponds to amino acid range 358-583 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L
基因别名: PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823
Entrez Gene ID: (Pig) 100048946, (Human) 6041
rRNA processing
mRNA processing
protein phosphorylation
regulation of mRNA stability
negative regulation of viral genome replication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
transmembrane transport
type I interferon signaling pathway
RNA phosphodiester bond hydrolysis, endonucleolytic
positive regulation of glucose import in response to insulin stimulus
