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Invitrogen
ROR2 Polyclonal Antibody
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ROR2 Antibody (PA5-14727) in IHC (P)
Immunohistochemistry analysis of ROR2 in formalin-fixed and paraffin-embedded human kidney carcinoma. Samples were incubated with ROR2 polyclonal antibody (Product # PA5-14727) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
产品信息
PA5-14727
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2
偶联物
形式
Liquid
浓度
2 mg/mL
规格
800 µg
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. It is thought to be involved in the early formation of the chondrocytes and cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; Tyrosine-protein kinase transmembrane receptor ROR2
基因别名: BDB; BDB1; NTRKR2; ROR2
UniProt ID: (Human) Q01974
Entrez Gene ID: (Human) 4920
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
coreceptor activity
kinase activity
transferase activity
Wnt-protein binding
mitogen-activated protein kinase kinase kinase binding
metal ion binding
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