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Invitrogen
RPE65 Polyclonal Antibody
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Product Details
PA5-110315
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 274-533 of human RPE65 (NP_000320.1).
Conjugate
Form
Liquid
Concentration
2.86 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NYMDCFESNE TMGVWLHIAD KKRKKYLNNK YRTSPFNLFH HINTYEDNGF LIVDLCCWKG FEFVYNYLYL ANLRENWEEV KKNARKAPQP EVRRYVLPLN IDKADTGKNL VTLPNTTATA ILCSDETIWL EPEVLFSGPR QAFEFPQINY QKYCGKPYTY AYGLGLNHFV PDRLCKLNVK TKETWVWQEP DSYPSEPIFV SHPDALEEDD GVVLSVVVSP GAGQKPAYLL ILNAKDLSEV ARAEVEINIP VTFHGLFKKS
Target Information
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: All-trans-retinyl-palmitate hydrolase; BCO family, member 3; Lutein isomerase; Meso-zeaxanthin isomerase; modifier of retinal degeneration 1; p63; RBP-binding membrane protein; retinal pigment epithelium 65-like; retinal pigment epithelium specific protein 65; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; Retinitis pigmentos; retinitis pigmentosa 20 (autosomal recessive); Retinoid isomerohydrolase; Retinol isomerase
Gene Aliases: 65kDa; A930029L06Rik; BCO3; LCA2; Mord1; mRPE65; rd12; RP20; RPE65; sRPE65
UniProt ID: (Human) Q16518, (Mouse) Q91ZQ5, (Rat) O70276
Entrez Gene ID: (Human) 6121, (Mouse) 19892, (Rat) 89826
phosphatidylserine binding
retinal isomerase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
phosphatidylcholine binding
metal ion binding
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
cardiolipin binding
hydrolase activity
isomerase activity
oxygenase
retinoid metabolic process
retina homeostasis
neural retina development
vitamin A metabolic process
regulation of rhodopsin gene expression
visual perception
circadian rhythm
insulin receptor signaling pathway
retinol metabolic process
retinal metabolic process
detection of light stimulus involved in visual perception
oxidation-reduction process
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
response to stimulus
retina development in camera-type eye
response to light stimulus
camera-type eye development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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