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Abnova
RSAD2 Monoclonal Antibody (4D10)
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产品信息
H00091543-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4D10
抗原
RSAD2 (NP_542388.2, 262 a.a. approximately 361 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: ALREAERFVI GDEEFERFLE RHKEVSCLVP ESNQKMKDSY LILDEYMRFL NCRKGRKDPS KSILDVGVEE AIKFSGFDEK MFLKRGGKYI WSKADLKLDW
靶标信息
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytomegalovirus-induced gene 5 protein; Radical S-adenosyl methionine domain-containing protein 2; RSAD2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
基因别名: 2510004L01Rik; cig33; CIG5; RSAD2; vig1
UniProt ID: (Human) Q8WXG1
Entrez Gene ID: (Human) 91543
response to virus
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
negative regulation of viral genome replication
negative regulation of protein secretion
defense response to virus
type I interferon signaling pathway
positive regulation of T-helper 2 cell cytokine production
