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Invitrogen
RUNX1 Recombinant Rabbit Monoclonal Antibody (3Y7V7)
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RUNX1 Antibody (MA5-58024) in WB
Western blot analysis of RUNX1 in SW620, Jurkat, and mouse testis (25 µg/lane). Samples were incubated overnight at 4°C with RUNX1 Recombinant Monoclonal Antibody (Product # MA5-58024) using a dilution of 1:1, 000. Followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) Secondary Antibody at 1:10,000 dilution. Blocking buffer: 3% nonfat dry milk in TBST; Exposure: 3 seconds.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-58024
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3Y7V7
抗原
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human RUNX1 (NP_001001890.1).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
Immunogen sequence: GTLVTVMAGN DENYSAELRN ATAAMKNQVA RFNDLRFVGR SGRGKSFTLT ITVFTNPPQV ATYHRAIKIT VDGPREPRRH RQKLDDQTKP GSLSFSERLS E
靶标信息
RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is essential for hematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta. RUNX1 is expressed in all tissues except brain and heart, with highest levels in thymus, bone marrow and peripheral blood.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acute myeloid leukemia 1 protein; AML-1; aml1 oncogene; CBF-alpha 2; CBF-alpha-2; core binding factor alpha 2; Core-binding factor subunit alpha-2; Oncogene AML-1; OTTHUMP00000108697; OTTHUMP00000108700; OTTHUMP00000108702; PEA2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; Runt-related transcription factor 1; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit
基因别名: AML1; CBF-alpha-2; CBFA2; Pebp2a2; Pebpa2b; RUNX1
Entrez Gene ID: (Mouse) 12394
regulatory region DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
calcium ion binding
protein binding
ATP binding
transcription factor binding
protein homodimerization activity
protein heterodimerization activity
repressing transcription factor binding
Runt transcription factor
skeletal system development
in utero embryonic development
liver development
myeloid progenitor cell differentiation
regulation of T cell anergy
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
central nervous system development
negative regulation of cell proliferation
regulation of signal transduction
hemopoiesis
myeloid cell differentiation
neuron differentiation
negative regulation of granulocyte differentiation
positive regulation of granulocyte differentiation
hair follicle morphogenesis
response to retinoic acid
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
embryonic hemopoiesis
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
behavioral response to pain
neuron development
definitive hemopoiesis
regulation of hair follicle cell proliferation
cellular response to transforming growth factor beta stimulus
positive regulation of cell maturation
positive regulation of progesterone secretion
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