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Abnova
RUSC1 Polyclonal Antibody, MaxPab™
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产品信息
H00023623-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RUSC1 (NP_055143.2, 1 a.a. approximately 433 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAEAQSGTGQ LQEQKKGLLI AVSVSVDKII SHFGAARNLV QKAQLGDSRL SPDVGHLVLT TLCPALHALV ADGLKPFRKD LITGQRRSSP WSVVEASVKP GSSTRSLGTL YSQVSRLAPL SSSRSRFHAF ILGLLNTKQL ELWFSSLQED AGLLSLLYLP TGFFSLARGG CPSLSTELLL LLQPLSVLTF HLDLLFEHHH HLPLGPPQAP APPGPPPALQ QTMQAMLHFG GRLAQSLRGT SKEAASDPSD SPNLPTPGSW WEQLTQASRV YASGGTEGFP LSRWAPGRHG TAAEEGAQER PLPTDEMAPG RGLWLGRLFG VPGGPAENEN GALKSRRPSS WLPPTVSVLA LVKRGAPPEM PSPQELEASA PRMVQTHRAV RALCDHTAAR PDQLSFRRGE VLRVITTVDE DWLRCGRDGM EGLVPVGYTS LVL
靶标信息
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AP-4 complex accessory subunit RUSC1; Nesca; New molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain-containing protein 1
基因别名: NESCA; RUSC1
UniProt ID: (Human) Q9BVN2
Entrez Gene ID: (Human) 23623
