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Invitrogen
RUSC1 Polyclonal Antibody
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产品信息
PA5-55885
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LEVRSSWSFA GVPGAQRLWM AEAQSGTGQL QEQKKGLLIA VSVSVDKIIS HFGAARNLVQ KAQLGDSRLS PDVG
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
靶标信息
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AP-4 complex accessory subunit RUSC1; Nesca; New molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain-containing protein 1
基因别名: 2210403N08Rik; AA408288; NESCA; RUSC1
UniProt ID: (Human) Q9BVN2, (Mouse) Q8BG26
Entrez Gene ID: (Human) 23623, (Mouse) 72296
