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NeoBiotechnologies
RXRB Monoclonal Antibody (PCRP-RXRB-2B6)
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Product Details
6257-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
PCRP-RXRB-2B6
Immunogen
Recombinant full-length human RXRB protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DADB-100D22.1; MGC1831; MHC class I promoter binding protein; Nuclear receptor subfamily 2 group B member 2; putative new variant; Retinoic acid receptor RXR-beta; retinoid X receptor; Retinoid X receptor beta; RXR Beta; unnamed protein product
Gene Aliases: DAUDI6; H-2RIIBP; NR2B2; RCoR-1; RXR-beta; RXRB; RXRbeta
UniProt ID: (Human) P28702
Entrez Gene ID: (Human) 6257
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
chromatin DNA binding
sequence-specific DNA binding
retinoic acid-responsive element binding
metal ion binding
sequence-specific double-stranded DNA binding
in utero embryonic development
maternal placenta development
regulation of transcription, DNA-templated
nervous system development
hormone-mediated signaling pathway
cell differentiation
positive regulation of bone mineralization
intracellular steroid hormone receptor signaling pathway
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
ventricular cardiac muscle cell differentiation
cardiac muscle cell proliferation
positive regulation of vitamin D receptor signaling pathway
cellular response to retinoic acid
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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