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Invitrogen
RYK Polyclonal Antibody
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产品信息
PA5-148880
产品规格
种属反应
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Ryk, Arg35-Arg211
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERK3; growth factor receptor; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
基因别名: AW536699; ERK-3; Mrk; Ryk; Vik
UniProt ID: (Mouse) Q01887
Entrez Gene ID: (Mouse) 20187
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
frizzled binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Wnt-protein binding
Wnt-activated receptor activity
transmembrane signal receptor
protein phosphorylation
signal transduction
axonogenesis
axon guidance
Wnt signaling pathway
phosphorylation
corpus callosum development
neuron differentiation
neuron projection development
positive regulation of MAPK cascade
skeletal system morphogenesis
negative regulation of axon extension involved in axon guidance
negative chemotaxis
commissural neuron axon guidance
