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Invitrogen
RbAp46 Polyclonal Antibody
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产品信息
PA1-868
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-868 detects retinoblastoma protein (Rb) associated protein 46 (RbAp46) from human cells.
PA1-868 has been successfully used in IF, Western blot and immunocytochemical procedures. By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 from HeLa cell lysate. Immunocytochemical staining of RbAp46 in HeLa cells with PA1-868 results in nuclear staining.
The PA1-868 immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. This sequence is completely conserved between human and mouse. This immunizing peptide (Cat. # PEP-083) is available for use in neutralization and control experiments.
靶标信息
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
基因别名: RBAP46; RBBP7
UniProt ID: (Human) Q16576
Entrez Gene ID: (Human) 5931
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription, DNA-templated
multicellular organism development
cell proliferation
histone deacetylation
negative regulation of cell growth
CENP-A containing nucleosome assembly
negative regulation of gene expression, epigenetic
response to steroid hormone
cellular heat acclimation
regulation of signal transduction by p53 class mediator
