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Invitrogen
Renin Polyclonal Antibody
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Renin Antibody (PA5-47577) in IHC (P)
Immunohistochemical analysis of Renin in immersion fixed paraffin-embedded sections of human kidney array. Samples were incubated in Renin polyclonal antibody (Product # PA5-47577) using a dilution of 10 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibo... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-47577
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human Renin Leu24-Arg406
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects both pro and mature forms of human Renin in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse Renin-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: angiotensin-forming enzyme; Angiotensinogenase; aspartyl-protease; EC 3.4.23; EC 3.4.23.15; FLJ10761; REN; Renin; renin precursor, renal; unnamed protein product
基因别名: ADTKD4; HNFJ2; REN; RTD
UniProt ID: (Human) P00797
Entrez Gene ID: (Human) 5972
kidney development
mesonephros development
angiotensin maturation
regulation of blood volume by renin-angiotensin
renin-angiotensin regulation of aldosterone production
regulation of blood vessel size by renin-angiotensin
proteolysis
regulation of blood pressure
male gonad development
response to xenobiotic stimulus
hormone-mediated signaling pathway
gene expression
response to lipopolysaccharide
response to immobilization stress
angiotensin-activated signaling pathway
drinking behavior
regulation of MAPK cascade
cell maturation
beta-amyloid metabolic process
response to cAMP
response to cGMP
cellular response to xenobiotic stimulus
juxtaglomerular apparatus development
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
