Rockland

Rho Monoclonal Antibody (4D2)

查看其他5个Rho Pan抗体

问题与答案

问题与答案

问题与答案

产品信息

200-301-G36

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫组化 (IHC)

1:1,000

-

免疫细胞化学 (ICC/IF)

Assay-dependent

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

免疫沉淀 (IP)

Assay-dependent

-

产品规格

种属反应

Amphibian, Avian, Fish, Mammal, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4D2

抗原

Rho Antibody was produced in mice by repeated immunizations raised against bovine Rhodopsin.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: plysia ras-related homolog A2; ras homolog family member F (in filopodia); ras homolog gene family, member A; ras homolog gene family, member B; ras homolog gene family, member C; ras homolog gene family, member Q; Ras-like protein TC10; ras-related GTP-binding protein TC10; rho family; Rho-related GTP-binding protein RhoB; rho-related GTP-binding protein RhoC; Rho-related GTP-binding protein RhoQ; rhoB; Transforming protein RhoA

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基因别名: Arha; Arha2; Arhb; Rhoa; Rhob; Rhoq; Tc10

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UniProt ID: (Rat) P61589, (Rat) P62747, (Rat) Q9JJL4

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Entrez Gene ID: (Rat) 117273, (Rat) 64373, (Rat) 295342, (Rat) 690130, (Rat) 85428

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GTPase activity protein binding GTP binding myosin binding GDP binding protein domain specific binding Rho GDP-dissociation inhibitor binding signal transducer activity profilin binding GBD domain binding small GTPase

cell morphogenesis response to hypoxia regulation of transcription from RNA polymerase II promoter cytoskeleton organization cell adhesion cell-matrix adhesion small GTPase mediated signal transduction skeletal muscle tissue development regulation of actin polymerization or depolymerization metabolic process response to mechanical stimulus response to glucose regulation of neuron projection development substantia nigra development cerebral cortex cell migration forebrain radial glial cell differentiation actin cytoskeleton organization cell differentiation positive regulation of cell growth regulation of cell migration positive regulation of cell migration androgen receptor signaling pathway positive regulation of actin filament polymerization stress-activated protein kinase signaling cascade positive regulation of cytokinesis negative regulation of intracellular steroid hormone receptor signaling pathway regulation of osteoblast proliferation cleavage furrow formation apolipoprotein A-I-mediated signaling pathway response to drug positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process apical junction assembly negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process ossification involved in bone maturation wound healing, spreading of cells response to ethanol negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of vasoconstriction positive regulation of smooth muscle contraction neuron projection morphogenesis regulation of dendrite development negative chemotaxis response to glucocorticoid positive regulation of stress fiber assembly regulation of calcium ion transport negative regulation of cell death trabecula morphogenesis cellular response to progesterone stimulus positive regulation of podosome assembly mitotic spindle assembly skeletal muscle satellite cell migration regulation of neural precursor cell proliferation angiogenesis intracellular protein transport obsolete transformed cell apoptotic process endosome to lysosome transport positive regulation of apoptotic process positive regulation of angiogenesis negative regulation of cell cycle cellular response to hydrogen peroxide cellular response to ionizing radiation actin filament organization insulin receptor signaling pathway regulation of cell shape cortical actin cytoskeleton organization cellular response to insulin stimulus positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import positive regulation of filopodium assembly negative regulation of establishment of protein localization to plasma membrane