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RhoA Recombinant Rabbit Monoclonal Antibody (3Z2Q9)

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RhoA Recombinant Rabbit Monoclonal Antibody (3Z2Q9)

产品信息

MA5-35266

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

3Z2Q9

抗原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RhoA (P61586)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.17 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2849168

产品详细信息

Immunogen sequence: MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT

靶标信息

RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. It is involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis, and plays an essential role in cleavage furrow formation. RhoA is required for the apical junction formation of keratinocyte cell-cell adhesion, and serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. RhoA stimulates PKN2 kinase activity and may be an activator of PLCE1. It is activated by ARHGEF2, which promotes the exchange of GDP for GTP. It is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Aplysia ras-related homolog 12; epididymis secretory sperm binding protein; h12; MGC72339; oncogene RHO H12; Rho; Rho cDNA clone 12; small GTP binding protein RhoA; Transforming protein RhoA; unnamed protein product

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基因别名: ARH12; ARHA; EDFAOB; RHO12; RHOA; RHOH12

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UniProt ID: (Human) P61586

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Entrez Gene ID: (Human) 387

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功能
nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity myosin binding protein kinase binding
参与通路
mitotic cytokinesis cell morphogenesis neuron migration kidney development angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure alpha-beta T cell lineage commitment regulation of systemic arterial blood pressure by endothelin aortic valve formation regulation of transcription from RNA polymerase II promoter cytoskeleton organization cell adhesion cell-matrix adhesion small GTPase mediated signal transduction Rho protein signal transduction skeletal muscle tissue development negative regulation of cell-substrate adhesion regulation of neuron projection development cell migration substantia nigra development cerebral cortex cell migration forebrain radial glial cell differentiation actin cytoskeleton organization cell differentiation regulation of cell migration positive regulation of cell migration androgen receptor signaling pathway cytoplasmic microtubule organization positive regulation of cytokinesis regulation of actin cytoskeleton organization negative regulation of intracellular steroid hormone receptor signaling pathway regulation of osteoblast proliferation cell junction assembly substrate adhesion-dependent cell spreading Roundabout signaling pathway cleavage furrow formation apolipoprotein A-I-mediated signaling pathway odontogenesis positive regulation of I-kappaB kinase/NF-kappaB signaling stress fiber assembly apical junction assembly beta selection endothelial cell migration ossification involved in bone maturation wound healing, spreading of cells establishment of epithelial cell apical/basal polarity positive regulation of neuron differentiation negative regulation of cell size positive regulation of alpha-beta T cell differentiation negative chemotaxis cell division positive regulation of stress fiber assembly regulation of focal adhesion assembly Wnt signaling pathway, planar cell polarity pathway positive regulation of lipase activity bone trabecula morphogenesis regulation of microtubule cytoskeleton organization cellular response to lipopolysaccharide cellular response to cytokine stimulus semaphorin-plexin signaling pathway positive regulation of podosome assembly positive regulation of protein serine/threonine kinase activity negative regulation of cell migration involved in sprouting angiogenesis mitotic spindle assembly negative regulation of oxidative phosphorylation motor neuron apoptotic process endothelial tube lumen extension regulation of modification of postsynaptic structure positive regulation of NIK/NF-kappaB signaling skeletal muscle satellite cell migration negative regulation of reactive oxygen species biosynthetic process mitotic cleavage furrow formation positive regulation of vascular smooth muscle contraction positive regulation of leukocyte adhesion to vascular endothelial cell regulation of modification of postsynaptic actin cytoskeleton cellular response to chemokine regulation of neural precursor cell proliferation positive regulation of T cell migration negative regulation of motor neuron apoptotic process
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