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Positive Control: ARHGAP1 transfected 293T cell
Predicted Reactivity: Mouse (99%), Rat (99%), Dog (99%), Rhesus Monkey (99%), Bovine (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells. It functions as a GTPase - activating protein (GAP) for Rho and Rac family proteins, which are involved in regulating cytoskeletal actin and membrane ruffling. The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP. The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CDC42 GTPase-activating protein; GFI2; GTPase-activating protein rhoGAP; GTPase-activating protein rhoOGAP; GTPase-activating protein, Rho, 1; p105 RhoGAP; p190BRhoGAP; p50-RhoGAP; Rho GTPase-activating protein 1; Rho-related small GTPase protein activator; Rho-type GTPase-activating protein 1; RhoGAP5
基因别名: ARHGAP1; CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1
UniProt ID: (Human) Q07960
Entrez Gene ID: (Human) 392
分子生物学功能: GTPase-activating protein