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Invitrogen
RyR1 Polyclonal Antibody
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RyR1 Antibody (PA5-115857) in IHC (P)
Immunohistochemistry analysis of RyR1 in mouse muscle tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RyR1 polyclonal antibody (Product # PA5-115857) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115857
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RYR1(Accession P21817), corresponding to amino acid residues E1113-L1163.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total RYR1.
靶标信息
Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscled cells. Ryanodine receptor, ~500 kDa, can be isolated from a variety of cell types such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscles, cardiac muscle and brain tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: central core disease of muscle; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor; ryanodine receptor 1 (skeletal); sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; type 1-like ryanodine receptor; unnamed protein product
基因别名: CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; SKRR
UniProt ID: (Human) P21817
Entrez Gene ID: (Human) 6261
response to hypoxia
outflow tract morphogenesis
ion transport
calcium ion transport
cellular calcium ion homeostasis
muscle contraction
striated muscle contraction
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
calcium-mediated signaling
response to caffeine
skin development
ossification involved in bone maturation
skeletal muscle fiber development
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of cytosolic calcium ion concentration
transmembrane transport
calcium ion transmembrane transport
cellular response to calcium ion
cellular response to caffeine
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