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Ryanodine Receptor Polyclonal Antibody

查看其他5个Ryanodine Receptor抗体

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Ryanodine Receptor Polyclonal Antibody

产品信息

PA5-109278

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:100
-

流式细胞分析 (Flow)

1:50-1:100
-

点杂交 (DB)

1:500
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide within Human RYR2 aa 1,471-1,520.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2854689

产品详细信息

Positive Control: 293T, LOVO, SH-SY-5Y, human fetal skeletal muscle tissue, mouse brain tissue, mouse cerebellum tissue, rat skeletal muscle tissue.

靶标信息

The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryanodine receptor; central core disease of muscle; islet-type ryanodine receptor; kidney-type ryanodine receptor; protein phosphatase 1, regulatory subunit 137; ryanodine receptor; ryanodine receptor 1 (skeletal); ryanodine receptor 2 (cardiac); sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; type 1-like ryanodine receptor; type 2 ryanodine receptor; unnamed protein product

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基因别名: ARVC2; ARVD2; CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR-2; SKRR; VACRDS; VTSIP

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UniProt ID: (Human) P21817, (Human) Q92736

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Entrez Gene ID: (Human) 6261, (Human) 6262

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功能
protease binding ion channel activity ryanodine-sensitive calcium-release channel activity voltage-gated calcium channel activity calcium channel activity calcium ion binding calmodulin binding ATP binding calcium-release channel activity enzyme binding calcium-induced calcium release activity protein binding protein kinase binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding identical protein binding suramin binding ion channel binding scaffold protein binding
参与通路
response to hypoxia regulation of heart rate embryonic heart tube morphogenesis left ventricular cardiac muscle tissue morphogenesis cardiac muscle hypertrophy detection of calcium ion ion transport calcium ion transport cellular calcium ion homeostasis striated muscle contraction response to nutrient response to xenobiotic stimulus positive regulation of heart rate regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to muscle activity calcium-mediated signaling response to caffeine response to magnesium ion ion transmembrane transport response to muscle stretch release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration negative regulation of cytosolic calcium ion concentration response to calcium ion response to redox state transmembrane transport regulation of cardiac muscle contraction cardiac muscle contraction calcium ion transport into cytosol sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport cellular response to caffeine manganese ion transmembrane transport cellular response to epinephrine stimulus ventricular cardiac muscle cell action potential Purkinje myocyte to ventricular cardiac muscle cell signaling cell communication by electrical coupling involved in cardiac conduction type B pancreatic cell apoptotic process positive regulation of the force of heart contraction regulation of AV node cell action potential regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential regulation of ventricular cardiac muscle cell action potential calcium ion export outflow tract morphogenesis muscle contraction skin development ossification involved in bone maturation skeletal muscle fiber development protein homotetramerization cellular response to calcium ion
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