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Invitrogen
S-arrestin Polyclonal Antibody
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产品信息
PA1-731
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Mouse,
Sheep,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: C E(347) V A T E V P F R L M H P Q P E D(363)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-731 detects recombinant bovine and sheep visual arrestin.
PA1-731 has been successfully used in immunofluorescence and Western blot procedures. By Western blot this antibody detects an ~57 kDa protein representing recombinant bovine and sheep visual arrestin. This antibody also detects a lower molecular weight protein which could correspond to degradation product.
The PA1-731 immunizing peptide corresponds to amino acid residues 2-18 from rat visual arrestin. This peptide (Cat. # PEP-155) is available for use in neutralization and control experiments.
靶标信息
S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 48 kDa protein; arrestin 1; arrestin-1; arrestin1; DKFZp686D1084; DKFZp686I1383; retinal S antigen; Retinal S-antigen; rod arrestin; Rod photoreceptor arrestin; S-AG; S-antigen; S-antigen; retina and pineal gland (arrestin); S-arrestin; visual arrestin 1
基因别名: A930001K18Rik; Arr1; arrestin; Irbp; S-AG; SAG; SAGMR; SANTI
UniProt ID: (Bovine) P08168, (Rat) P15887, (Mouse) P20443
Entrez Gene ID: (Sheep) 101105037, (Bovine) 280922, (Rat) 25539, (Mouse) 20215
