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Invitrogen
S-arrestin Monoclonal Antibody (PDS-1)
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S-arrestin Antibody (MA1-16962) in IHC (P)
Immunohistochemistry analysis of S-arrestin in immersion fixed paraffin-embedded sections of human prostate cancer. Samples were incubated with S-arrestin monoclonal antibody (Product # MA1-16962) using a dilution of 1:300 for 1 hour at room temperature followed by Anti-Mouse IgG VisUCyte HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining... View More
产品信息
MA1-16962
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Pig
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
PDS-1
抗原
Porcine retinal S-arrestin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Suggested positive control: retina lysate.
靶标信息
S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 48 kDa protein; arrestin 1; arrestin-1; arrestin1; DKFZp686D1084; DKFZp686I1383; photoreceptor protein/alleged cGMP phosphodiesterase activation modulator; retinal S antigen; Retinal S-antigen; retinal S-antigen (48 KDa protein); rod arrestin; Rod photoreceptor arrestin; S-AG; S-antigen; S-antigen; retina and pineal gland (arrestin); S-arrestin
基因别名: RP47; S-AG; SAG
UniProt ID: (Pig) P79260, (Bovine) P08168, (Human) P10523
Entrez Gene ID: (Pig) 397151, (Bovine) 280922, (Human) 6295
