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Invitrogen
S-arrestin Monoclonal Antibody (S128)
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FIGURE: 1 / 3
S-arrestin Antibody (MA5-47477) in IHC
Immunohistochemistry analysis of S-arrestin in pig retina. Samples were stained with S-arrestin monoclonal antibody (Product # MA5-47477) in green. Arrestin 1 is most abundant in the outer segments (OS) and inner surface of the outer nuclear layer (ONL), and can be used to identify components of rod photoreceptor cells (cone photoreceptors have a different arrestin isotype). Other retinal layers are inner segments (IS), outer plexiform layer (OPL), inner nuclear layer (INL) and inner plexiform layer (IPL). The red stain shows staining for ... View More
Product Details
MA5-47477
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Horse,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
S128
Immunogen
Recombinant bovine arrestin 1 with the first 20 amino acids of the C-terminus truncated
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 48 kDa protein; arrestin 1; arrestin-1; arrestin1; DKFZp686D1084; DKFZp686I1383; photoreceptor protein/alleged cGMP phosphodiesterase activation modulator; retinal S antigen; Retinal S-antigen; retinal S-antigen (48 KDa protein); rod arrestin; Rod photoreceptor arrestin; S-AG; S-antigen; S-antigen; retina and pineal gland (arrestin); S-arrestin; visual arrestin 1
Gene Aliases: A930001K18Rik; Arr1; arrestin; Irbp; RP47; S-AG; SAG; SAGMR; SANTI
UniProt ID: (Pig) P79260, (Bovine) P08168, (Human) P10523, (Rat) P15887, (Mouse) P20443
Entrez Gene ID: (Pig) 397151, (Bovine) 280922, (Human) 6295, (Rat) 25539, (Mouse) 20215
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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