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S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD antigen CD363; CD363 antigen; Edg1; rhodopsin family G protein-coupled receptor; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; S1P receptor 1; S1P receptor Edg-1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1
基因别名: edg1; etID43307.22; s1p1; s1pr1; wu:fb98f05
UniProt ID: (Zebrafish) Q9DDK4
Entrez Gene ID: (Zebrafish) 64617
分子生物学功能: G-protein coupled receptor