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Agrisera
S6K1/2/Ribosomal S6 kinase 1/2 Polyclonal Antibody
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S6K1/2/Ribosomal S6 kinase 1/2 Antibody (AS12-1855) in WB
20 µg of total protein from flowers and leaves of transgenic Arabidopsis thaliana lines were analyzed (expressing the genomic copy of S 6 K 1 tagged with FLAG epitope under the control of its own promoter) extracted with homogenization buffer were separated on 10% SDS-PAGE and blotted 2 h to PVDF. Blots were blocked with 5% milk in TBST for 1 h at room temperature (RT) with agitation. Blot was incubated in ... View More
产品信息
AS12-1855
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide, derived from Arabidopsis thaliana.
偶联物
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles,Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
S6K1/2 encode closely related AGC-family serine/threonine kinases that act predominantly in the cytoplasm but can also be detected in the nucleus in an isoform- and phosphorylation-dependent manner. They are soluble proteins (no transmembrane segments) built around a conserved central protein kinase catalytic domain flanked by divergent N- and C-terminal regulatory regions; activation requires multisite phosphorylation, including hydrophobic-motif phosphorylation (classically at Thr389 in S6K1) that promotes the active kinase conformation and facilitates activation-loop phosphorylation by PDK1. Functionally, S6K1 and S6K2 are major downstream effectors of mTORC1 signaling: once activated, they phosphorylate ribosomal protein S6 and additional translation-related substrates such as eIF4B, thereby promoting ribosome biogenesis and selective translation programs (including 5prime TOP mRNAs), which drives anabolic growth, increased protein synthesis, and cell proliferation; consistent with this role, altered S6K signaling is frequently linked to growth control and cancer-relevant phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KLS; p70 S6KA; P70(S6K)-ALPHA; p70(S6K)-beta; p70-alpha; P70-beta; P70-beta-1; P70-beta-2; p70-S6K; p70-S6K 2; p70S6Kb; PS6K; RPS6KB1; RPS6KB2; S6K; S6K-beta-1; S6K-beta-2; S6K-beta2; S6K1; S6K2; S6KB; S6Kbeta; S6KI(2); SRK; STK14A; STK14B
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