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Invitrogen
SAMHD1 Polyclonal Antibody
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SAMHD1 Antibody (PA5-96811) in IHC (P)
Immunohistochemistry analysis of SAMHD1 in paraffin-embedded human liver cancer. Samples were incubated with SAMHD1 Polyclonal antibody (Product # PA5-96811) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96811
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 387-626 of human SAMHD1 (NP_0562892)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.12 mg/mL
规格
112 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TDAFLKADDY IEITGAGGKK YRISTAIDDM EAYTKLTDNI FLEILYSTDP KLKDAREILK QIEYRNLFKY VGETQPTGQI KIKREDYESL PKEVASAKPK VLLDVKLKAE DFIVDVINMD YGMQEKNPID HVSFYCKTAP NRAIRITKNQ VSQLLPEKFA EQLIRVYCKK VDRKSLYAAR QYFVQWCADR NFTKPQDGDV IAPLITPQKK EWNDSTSVQN PTRLREASKS RVQLFKDDPM; Positive Samples: HepG2, HeLa, MCF-7, Mouse spleen; Cellular Location: Nucleus
靶标信息
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dendritic cell-derived IFNG-induced protein; dNTPase; IFN-gamma induced; interferon-gamma-inducible protein Mg11; monocyte protein 5; RP1-132F21.1; SAM domain and HD domain 1; SAM domain and HD domain, 1; SAM domain and HD domain-containing protein 1; unknown intracellular protein; unnamed protein product
基因别名: CHBL2; DCIP; E330031J07Rik; HDDC1; hSAMHD1; Mg11; MOP-5; mSAMHD1; SBBI88
UniProt ID: (Human) Q9Y3Z3, (Mouse) Q60710
Entrez Gene ID: (Human) 25939, (Mouse) 56045, (Rat) 311580
double-strand break repair via homologous recombination
dGTP catabolic process
immune response
cellular response to DNA damage stimulus
deoxyribonucleotide catabolic process
somatic hypermutation of immunoglobulin genes
regulation of innate immune response
dATP catabolic process
protein homotetramerization
defense response to virus
negative regulation of type I interferon-mediated signaling pathway
DNA strand resection involved in replication fork processing
modulation by host of viral RNA genome replication
positive regulation of transcription, DNA-templated
negative regulation of viral life cycle
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