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Alomone Labs, LTD

SAP-97/DLG1 Polyclonal Antibody

查看其他18个SAP97抗体

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SAP-97/DLG1 Polyclonal Antibody

产品信息

APZ-010-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)EYRSKLSQTEDRQLR, corresponding to amino acid residues 17-31 of human SAP-97, N-terminus, L27 domain
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

规格

160 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; dJ1061C18.1.1; DKFZp761P0818; DKFZp781B0426; DLG1; E-dlg/SAP97; Drosophila discs-large tumor suppressor homologue (synapse associated protein); embryo-dlg/synapse-associated protein 97; presynaptic protein SAP97; synapse-associated protein 97; unnamed protein product

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基因别名: B130052P05Rik; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97

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UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q811D0

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Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383

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功能
guanylate kinase activity phosphoprotein phosphatase activity protein binding cytoskeletal protein binding potassium channel regulator activity kinase binding protein kinase binding phosphatase binding ionotropic glutamate receptor binding ion channel binding cadherin binding binding, bridging L27 domain binding structural constituent of postsynaptic density kinesin binding enzyme binding PDZ domain binding
参与通路
negative regulation of transcription from RNA polymerase II promoter endothelial cell proliferation actin filament organization establishment or maintenance of cell polarity chemical synaptic transmission nervous system development regulation of cell shape cortical actin cytoskeleton organization astral microtubule organization protein complex localization regulation of protein localization protein localization to synapse regulation of membrane potential receptor clustering regulation of potassium ion transport positive regulation of potassium ion transport cortical microtubule organization establishment or maintenance of epithelial cell apical/basal polarity GMP metabolic process GDP metabolic process establishment of centrosome localization negative regulation of ERK1 and ERK2 cascade bicellular tight junction assembly protein localization to membrane protein localization to plasma membrane receptor localization to synapse cell-cell adhesion regulation of ventricular cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential regulation of postsynaptic membrane neurotransmitter receptor levels maintenance of postsynaptic density structure neurotransmitter receptor localization to postsynaptic specialization membrane regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport regulation of protein localization to synapse positive regulation of protein localization to plasma membrane regulation of potassium ion import negative regulation of p38MAPK cascade regulation of potassium ion export across plasma membrane protein localization to cell periphery negative regulation of G1/S transition of mitotic cell cycle ureteric bud development branching involved in ureteric bud morphogenesis immunological synapse formation lens development in camera-type eye cell adhesion protein localization positive regulation of cell proliferation positive regulation of gene expression epithelial structure maintenance cerebral cortex development peristalsis positive regulation of actin filament polymerization membrane raft organization regulation of myelination activation of protein kinase activity T cell activation negative regulation of T cell proliferation amyloid precursor protein metabolic process reproductive structure development embryonic skeletal system morphogenesis tissue morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation negative regulation of protein kinase B signaling hard palate development cellular response to brain-derived neurotrophic factor stimulus positive regulation of multicellular organism growth positive regulation of developmental growth
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