Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
SAP18 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
PA5-76167
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of human SAP18.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
SAP18 is involved in histone acetylation, which plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 18 kDa Sin3-associated polypeptide; 2HOR0202; cell growth inhibiting protein 38; Cell growth-inhibiting gene 38 protein; cell growth-inhibiting protein 38; histone deacetlyase complex subunit SAP18; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide p18; sin3-associated polypeptide, 18 kDa; sin3-associated polypeptide, 18kDa; sin3-associated polypeptide, p18; Sin3A associated protein 18kDa; Sin3A-associated protein, 18kDa
基因别名: 2HOR0202; C530046K05Rik; D11Ertd539e; EMegR4; GIG38; SAP18; SAP18P; Sinbp1
UniProt ID: (Human) O00422, (Mouse) O55128
Entrez Gene ID: (Human) 10284, (Mouse) 20220, (Rat) 290284
regulation of alternative mRNA splicing, via spliceosome
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
mRNA processing
RNA splicing
histone deacetylation
positive regulation of apoptotic process
negative regulation of mRNA splicing, via spliceosome
negative regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
chromatin modification
biological_process
