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Invitrogen
SARS-CoV-2 NSP1 Recombinant Rabbit Monoclonal Antibody (HL1435)
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SARS-CoV-2 NSP1 Antibody (MA5-47043) in ICC/IF
Immunocytochemistry analysis of SARS-CoV-2 NSP1 in paraffin-embedded SARS-CoV-2 (COVID-19) nsp1 transfected 293T. Green: SARS-CoV-2 (COVID-19) nsp1 stained by SARS-CoV-2 (COVID-19) nsp1 monoclonal antibody (Product # MA5-47043) diluted at 1:1,000. Blue: Fluoroshield with DAPI. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
MA5-47043
应用
建议稀释比
已发表文章
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1435
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of SARS-CoV-2 (COVID-19) nsp1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
Inhibits host translation by interacting with the 40S ribosomal subunit (PubMed:32680882). Nsp1 C terminus binds to and obstructs ribosomal mRNA entry tunnel (PubMed:32680882). Thereby inhibits antiviral response triggered by innate immunity or interferons (PubMed:32680882). The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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