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Predicted reactivity based on immunogen sequence: SARS-CoV ORF9b proteins: (50%)
ORF9b plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.
仅用于科研。不用于诊断过程。未经明确授权不得转售。