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Abnova
SARS-CoV Nucleoprotein/NP Recombinant Rabbit Monoclonal Antibody
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产品信息
RAB01765
应用
建议稀释比
已发表文章
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant protein corresponding to SARS-CoV Nucleoprotein/NP protein.
偶联物
形式
Lyophilized
纯化类型
Affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The SARS-CoV Nucleoprotein, or nucleocapsid (N) protein, is a fundamental structural component of the SARS-CoV virus, which belongs to the family of coronaviruses. Like its relative, SARS-CoV-2, the N protein is vital for viral replication and packaging, interacting closely with the viral RNA to form the ribonucleoprotein complex. The N protein is encoded by the positive-sense, single-stranded RNA genome of the virus, which is composed of approximately 30 proteins facilitating various functions such as cell penetration, replication, and transcription. With a molecular weight of approximately 46 kDa, the SARS-CoV N protein shares about 89.1% sequence identity with the nucleocapsid protein of SARS-CoV-2. The protein's structure is characterized by two distinct domains: the N-terminal RNA-binding domain and the C-terminal dimerization domain. These domains work synergistically to provide structural integrity and facilitate critical interactions with other viral and host proteins. Researchers are keen on exploring the N protein as a target for vaccine development, considering its significant role in viral pathogenesis and immune evasion. It plays a crucial role in modulating antiviral responses by interacting with host cell proteins, potentially affecting global gene expression and translation processes in the host.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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