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Invitrogen
SATB2 Recombinant Rabbit Monoclonal Antibody (9D1)
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图: 1 / 8
SATB2 Antibody (MA573443) in ICC/IF
Immunocytochemistry analysis of SATB2 in THP-1 cells. Permeabilized with Trinton X-100 at room temp for 20 min. Samples were incubated with SATB2 Recombinant Monoclonal (Product # MA573443 using a dilution at 1:100, for 90 min at 37°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green) at 37°C for 90 min, DAPI was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
产品信息
MA573443
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9D1
抗原
KLH conjugated synthetic peptide derived from human SATB2.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034-like DNA binding protein; MGC119474; MGC119477; SATB family member 2; SATB2 fusion; special AT-rich sequence binding protein 2; Special AT-rich sequence-binding protein 2; truncated protein after SATB2; two cut domains-containing homeodomain protein; unnamed protein product
基因别名: C2DELq32q33; DEL2Q32Q33; GLSS; KIAA1034; mKIAA1034; RGD1562369; SATB2
UniProt ID: (Human) Q3ZB87, (Mouse) Q8VI24
Entrez Gene ID: (Human) 23314, (Mouse) 212712, (Rat) 501145
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
histone deacetylase binding
sequence-specific DNA binding
helix-turn-helix transcription factor
DNA-binding transcription factor
Lambda repressor-like transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
neuron migration
osteoblast development
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
embryonic pattern specification
regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
cartilage development
palate development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
chromatin modification
commitment of neuronal cell to specific neuron type in forebrain
cellular response to organic substance
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