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Invitrogen
SAV1 Recombinant Rabbit Monoclonal Antibody (PSH04-45)
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SAV1 Antibody (MA5-56419) in IHC (P)
Immunohistochemistry analysis of SAV1 with paraffin-embedded mouse testis tissue. The tissues were blocked in 1% BSA (20 min, room temp), washed with ddH2O and PBS, incubated with SAV1 Recombinant Monoclonal Antibody (Product # MA5-56419) at a dilution of 1:1,000 (1 hr, room temp).
产品信息
MA5-56419
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH04-45
抗原
Recombinant protein within human SAV1 aa 1-383/383.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1700040G09Rik; 45 kDa WW domain protein; hWW45; mWW45; Protein salvador homolog 1; rWW45; salvador homolog 1; Salvador homolog 1 protein; sav1 {ECO:0000312|EMBL:CAJ98868.1}; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4
基因别名: 1700040G09Rik; Salv; SAV; SAV1; WW45; Wwp3; WWP4
UniProt ID: (Human) Q9H4B6, (Mouse) Q8VEB2, (Rat) A4V8B4
Entrez Gene ID: (Human) 60485, (Mouse) 64010, (Rat) 299116
hair follicle development
signal transduction
keratinocyte differentiation
hippo signaling
positive regulation of apoptotic process
positive regulation of fat cell differentiation
regulation of organ growth
negative regulation of epithelial cell proliferation
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of cardiac muscle cell proliferation
ventricular septum morphogenesis
lung epithelial cell differentiation
intestinal epithelial cell differentiation
regulation of stem cell population maintenance
