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Invitrogen
SCIN Recombinant Rabbit Monoclonal Antibody (23GB4135)
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SCIN Antibody (MA5-52658) in ICC/IF
Immunocytochemistry analysis of SCIN in HepG2 cells. Nuclei were stained blue with DAPI; SCIN recombinant monoclonal antibody (Product # MA5-52658) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
产品信息
MA5-52658
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB4135
抗原
A synthesized peptide derived from human SCIN (650-715AA).
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adseverin; Gelsolin-like protein; Scinderin
基因别名: adseverin; AW545522; KIAA1905; SCIN; Scind
UniProt ID: (Human) Q9Y6U3, (Mouse) Q60604
Entrez Gene ID: (Human) 85477, (Rat) 298975, (Mouse) 20259
negative regulation of cell proliferation
calcium ion regulated exocytosis
regulation of chondrocyte differentiation
sequestering of actin monomers
positive regulation of apoptotic process
actin nucleation
positive regulation of megakaryocyte differentiation
actin filament severing
positive regulation of secretion
positive regulation of actin nucleation
actin filament capping
