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SCN2B (NaV beta 2) Polyclonal Antibody

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说明书
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说明书
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SCN2B (NaV beta 2) Polyclonal Antibody

产品信息

ASC-007-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化 (IHC)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)KTEEEGKTDGEGNAEDGAK, corresponding to amino acid residues 197-215 of rat beta 2subunit of voltage-gated Na+channels, Intracellular, C-terminus
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.75 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Scn2b is a member of voltage-gated sodium channels (NaV) that are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn2b are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Scn2b is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. In Scn2b, the subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Also, Scn2b interacts with TNR (Tenascin R-precursor) and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. The protein encoded by the Scn2b gene is the beta 2 subunit of the type II voltage-gated sodium channel. Scn2b protein is involved in cell-cell adhesion and cell migration. Defects in the Scn2b gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Scn2b-Related Familial Atrial Fibrillation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: neuronal voltage-gated sodium channel beta 2 subunit; Sodium channel beta 2; Sodium channel regulatory subunit beta-2; sodium channel subunit beta-2; sodium channel, voltage gated, type II beta subunit; sodium channel, voltage-gated, type II, beta polypeptide

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基因别名: 2810451E09Rik; AI840361; ATFB14; Gm183; SCN2B; SCNB2; UNQ326/PRO386

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UniProt ID: (Human) O60939, (Rat) P54900, (Mouse) Q56A07

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Entrez Gene ID: (Human) 6327, (Rat) 25349, (Mouse) 72821

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