Invitrogen

SCN5A Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Tech Support
SCN5A Polyclonal Antibody

Product Details

PA5-115620

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SCN5A(Accession Q14524), corresponding to amino acid residues E473-R523.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900255

Product Specific Information

Antibody detects endogenous levels of total Nav1.5.

Target Information

Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Scn5a is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in Scn5a are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms of Scn5a. Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts. Further, Scn5a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn5a forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Functionally, Scn5a is responsible for the initial upstroke of the action potential and the channel inactivation is regulated by intracellular calcium levels. Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn5a are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Diseases associated with SCN5A include Long Qt Syndrome-3 and Brugada Syndrome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2VF1; CIN5; hH1; HH1CMD1E; LQT3SSS1CMPD2; mH1; RATRSKM2X; RH1; RSkM2; RSKM2X; Scn2x; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; voltage-gated sodium channel Nav1.5c; Voltage-gated sodium channel subunit alpha Nav1.5

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Gene Aliases: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; mH1; Nav1.5; Nav1.5c; PFHB1; SCAL; SCN5A; SkM1; SkM2; SSS1; VF1

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UniProt ID: (Human) E9PEK2, (Rat) P15389, (Mouse) Q9JJV9

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Entrez Gene ID: (Human) 6331, (Rat) 25665, (Mouse) 20271

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Function(s)
voltage-gated sodium channel activity protein binding calmodulin binding fibroblast growth factor binding enzyme binding protein kinase binding protein domain specific binding ankyrin binding ubiquitin protein ligase binding ion channel binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity involved in AV node cell action potential voltage-gated sodium channel activity involved in bundle of His cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential voltage-gated sodium channel activity involved in SA node cell action potential scaffold protein binding ion channel activity voltage-gated ion channel activity sodium channel activity voltage-gated ion channel
Process(es)
regulation of heart rate cardiac ventricle development brainstem development sodium ion transport positive regulation of sodium ion transport response to denervation involved in regulation of muscle adaptation neuronal action potential telencephalon development cerebellum development sodium ion transmembrane transport odontogenesis of dentin-containing tooth positive regulation of action potential positive regulation of epithelial cell proliferation membrane depolarization cardiac muscle contraction regulation of postsynaptic membrane potential regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization regulation of atrial cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction cellular response to calcium ion cardiac muscle cell action potential involved in contraction regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane depolarization during action potential membrane depolarization during cardiac muscle cell action potential SA node cell action potential AV node cell action potential bundle of His cell action potential membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential AV node cell to bundle of His cell communication regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transport positive regulation of heart rate response to organic cyclic compound regulation of ion transmembrane transport bundle of His cell to Purkinje myocyte communication SA node cell to atrial cardiac muscle cell communication transport ion transport transmembrane transport
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