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Invitrogen
SEMA3F Polyclonal Antibody
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SEMA3F Antibody (PA5-67974) in IHC (P)
Immunohistochemical analysis of SEMA3F in paraffin-embedded human meningioma tissue. 1) SEMA3F Polyclonal Antibody (Product # PA5-67974) was diluted at 1:200 (4° overnight). 2) Tris-EDTA,pH9.0 was used for antigen retrieval. 3) Secondary antibody was diluted at 1:200 (room temperature, 45 min).
产品信息
PA5-67974
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human SEMA3F.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with Mouse and Rat samples.
靶标信息
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3F; Sema III/F; Sema IV; semaphorin 3F; semaphorin III/F; Semaphorin IV; Semaphorin-3F
基因别名: SEMA-IV; SEMA3F; SEMA4; SemaIV; SEMAK
UniProt ID: (Human) Q13275, (Mouse) O88632
Entrez Gene ID: (Human) 6405, (Mouse) 20350, (Rat) 315996
neural crest cell migration
axon guidance
facial nerve structural organization
trigeminal nerve structural organization
nerve development
branchiomotor neuron axon guidance
positive regulation of cell migration
ventral trunk neural crest cell migration
negative regulation of axon extension involved in axon guidance
axon extension involved in axon guidance
negative chemotaxis
sympathetic ganglion development
semaphorin-plexin signaling pathway
sympathetic neuron projection extension
sympathetic neuron projection guidance
neural crest cell migration involved in autonomic nervous system development
semaphorin-plexin signaling pathway involved in neuron projection guidance
semaphorin-plexin signaling pathway involved in axon guidance
