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Invitrogen
SEMA5B Monoclonal Antibody (C3)
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SEMA5B Antibody (MA5-43588) in IHC (P)
Immunohistochemistry of SEMA5B in paraffin-embedded human cardiac muscle tissue. Samples were incubated in monoclonal SEMA5B antibody (Product # MA5-43588) using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.
产品信息
MA5-43588
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
C3
抗原
Gly350-Pro602 (Accession Q9P283), with N-terminal His Tag
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Semaphorin 5B (SEMA5B) is a gene belonging to the Semaphorin family, which is known for its role as guidance cues in various biological processes. The gene is located on chromosome 3q21.3 and encodes for the transmembrane protein Semaphorin 5B, which participates significantly in neural development and cancer processes. SEMA5B serves as a guidance cue in neural tissues, impacting axonal growth and branching by acting through receptors like PlexinA1. It is proteolytically processed from its transmembrane form to a soluble form, capable of collapsing growth cones in neurons, thereby regulating neuronal pathfinding. Studies have revealed that SEMA5B impacts sensory afferent projections through interactions with cell adhesion molecules such as TAG-1. Moreover, SEMA5B has been implicated in cancer, particularly showing upregulated expression in kidney renal clear cell carcinoma (KIRC) at both mRNA and protein levels. Its expression correlates with various clinical parameters, including tumor stage and patient demographics. Its dynamic expression pattern in the spinal cord suggests a role in the modulation of sensory axon growth, further emphasizing its importance in developmental neurobiology and pathology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; Semaphorin-5B
基因别名: KIAA1445; SEMA5B; SEMAG; SemG; UNQ5867/PRO34001
UniProt ID: (Human) Q9P283
Entrez Gene ID: (Human) 54437
