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Invitrogen
SEMA7A Recombinant Rabbit Monoclonal Antibody (K01_2P42)
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产品信息
MA564204
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2P42
抗原
Recombinant protein of human Semaphorin 7a (aa 45-648).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QGHLRSGPRI FAVWKGHVGQ DRVDFGQTEP HTVLFHEPGS SSVWVGGRGK VYLFDFPEGK NASVRTVNIG STKGSCLDKR DCENYITLLE RRSEGLLACG TNARHPSCWN LVNGTVVPLG EMRGYAPFSP DENSLVLFEG DEVYSTIRKQ EYNGKIPRFR RIRGESELYT SDTVMQNPQF IKATIVHQDQ AYDDKIYYFF REDNPDKNPE APLNVSRVAQ LCRGDQGGES SLSVSKWNTF LKAMLVCSDA ATNKNFNRLQ DVFLLPDPSG QWRDTRVYGV FSNPWNYSAV CVYSLGDIDK VFRTSSLKGY HSSLPNPRPG KCLPDQQPIP TETFQVADRH PEVAQRVEPM GPLKTPLFHS KYHYQKVAVH RMQASHGETF HVLYLTTDRG TIHKVVEPGE QEHSFAFNIM EIQPFRRAAA IQTMSLDAER RKLYVSSQWE VSQVPLDLCE VYGGGCHGCL MSRDPYCGWD QGRCISIYSS ERSVLQSINP AEPHKECPNP KPDKAPLQKV SLAPNSRYYL SCPMESRHAT YSWRHKENVE QSCEPGHQSP NCILFIENLT AQQYGHYFCE AQEGSYFREA QHWQLLPEDG IMAEHLLGHA CALA
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 29%, Pig - 86%, Cynomolgus monkey - 98%.
靶标信息
CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors - plexin C1 and beta1 integrins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD108; CDw108; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; John-Milton-Hargen human blood group Ag; MGC126692; MGC126696; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Semaphorin-7A; Semaphorin-K1; Semaphorin-L
基因别名: CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMA7A; SEMAK1; SEMAL
UniProt ID: (Human) O75326
Entrez Gene ID: (Human) 8482
osteoblast differentiation
neural crest cell migration
inflammatory response
immune response
integrin-mediated signaling pathway
olfactory lobe development
positive regulation of cell migration
positive regulation of axon extension
axon extension
negative regulation of axon extension involved in axon guidance
regulation of inflammatory response
negative chemotaxis
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
