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Invitrogen
SETD6 Recombinant Rabbit Monoclonal Antibody (1Q1Z3)
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SETD6 Antibody (MA5-51377) in WB
Western blot analysis of SETD6 in various lysates. Samples were incubated with SETD6 Recombinant monoclonal antibody (Product # MA5-51377) using a dilution of 1:2,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-51377
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1Q1Z3
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 310-473 of human SETD6 (NP_001153777.1).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.63 mg/mL
规格
63 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TADIQMVTVR EAALQGTKTE AERHLVYERW DFLCKLEMVG EEGAFVIGRE EVLTEEELTT TLKVLCMPAE EFRELKDQDG GGDDKREEGS LTITNIPKLK ASWRQLLQNS VLLTLQTYAT DLKTDQGLLS NKEVYAKLSW REQQALQVRY GQKMILHQLL ELTS
靶标信息
SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates "Lys-310" of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SET domain-containing protein 6; unnamed protein product
基因别名: 0610039J04Rik; 3110004G14Rik; RGD1560538
UniProt ID: (Human) Q8TBK2, (Rat) D3ZSK5, (Mouse) Q9CWY3
Entrez Gene ID: (Human) 79918, (Rat) 291844, (Mouse) 66083
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