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Invitrogen
SETDB2 Polyclonal Antibody
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图: 1 / 2
SETDB2 Antibody (PA5-100857) in ICC/IF
Immunocytochemistry analysis of SETDB2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SETDB2 polyclonal antibody (Product # PA5-100857) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-100857
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SETDB2(Accession Q96T68), corresponding to amino acid residues M1-Q33.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SETDB2.
靶标信息
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 ).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bifurcated 2; chronic lymphocytic leukemia deletion region gene 8 protein; CLLL8 protein; DKFZp586I0123; DKFZp761J1217; isoform lacks exon 4; lysine N-methyltransferase 1F; SET domain; SET domain bifurcated 2; similar to Setdb2 variant A but lacks 47 bps within exon 1; similar to Setdb2 variant A but utilizes an alternate splice acceptor site between exons 11 and 12, which results in a frame shift mutation and a premature stop codon; unnamed protein product; variant starts in exon 2
基因别名: C13orf4; CLLD8; CLLL8; Gm293; KMT1F
UniProt ID: (Human) Q96T68
Entrez Gene ID: (Human) 83852, (Mouse) 239122
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