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Invitrogen
SETMAR Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-18116
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (RWQKCVDCNGSYFD) corresponding to the C-terminus amino acids of SETMAR (aa 671-684).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
SETMAR (SET domain and mariner transposase fusion gene) is a histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, creating specific tags for epigenetic transcriptional activation. It specifically mediates dimethylation of H3 Lys-36. SETMAR has sequence-specific DNA-binding activity, and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 transposable element. SETMAT has DNA nicking activity, and in vivo end-joining activity, and may mediate genomic integration of foreign DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: methylase and endonuclease; orf; encodes putative chimeric protein with SET domain in N-terminus with similarity to several other human, Drosophila, nematode and yeast proteins; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein; unnamed protein product
基因别名: Mar1; METNASE
UniProt ID: (Human) Q53H47
Entrez Gene ID: (Human) 6419
single-stranded DNA endodeoxyribonuclease activity
nucleic acid binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
endonuclease activity
protein binding
zinc ion binding
protein-lysine N-methyltransferase activity
histone methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
protein homodimerization activity
DNA topoisomerase binding
histone methyltransferase activity (H3-K36 specific)
histone H3 methyltransferase activity
histone H3K36 dimethyltransferase activity
DNA double-strand break processing
double-strand break repair via nonhomologous end joining
DNA catabolic process
chromatin remodeling
cell proliferation
DNA integration
replication fork processing
mitotic DNA integrity checkpoint
nucleic acid metabolic process
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
positive regulation of double-strand break repair via nonhomologous end joining
negative regulation of chromosome organization
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