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Rockland
SFTS Virus HB29 Polyclonal Antibody
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产品信息
600-401-EH1
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-SFTS Virus HB29 Membrane Glycoprotein antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the internal region of human SFTS Virus HB29 Membrane Glycoprotein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Severe Fever with Thrombocytopenia Syndrome (SFTS) virus HB29 is a strain of the SFTS virus, a member of the genus Phlebovirus within the family Phenuiviridae. SFTS virus is primarily transmitted through tick bites, and the HB29 strain was identified as causing significant morbidity and mortality in regions of China, Korea, and Japan. The viral genome comprises three single-stranded RNA segments: L (large), M (medium), and S (small), encoding the RNA-dependent RNA polymerase, glycoproteins (Gn and Gc), and non-structural proteins. HB29's unique features include genetic differences that might contribute to its virulence and transmission dynamics. Infections with SFTS virus, including the HB29 strain, present clinically with severe symptoms such as high fever, thrombocytopenia, leukocytopenia, multiorgan failure, and hemorrhagic manifestations. The pathogenesis involves immune evasion techniques, such as suppressing host immune responses by targeting cellular signaling pathways. Understanding the genetic and molecular characteristics of the HB29 strain, including its interaction with host cells and immune modulation, is crucial for developing diagnostic tools, vaccines, and antiviral therapies effective against this virulent pathogen.
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