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Invitrogen
SFXN4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-98509
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Sideroflexin-4 protein (2-110AA)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
4.28 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Sideroflexin 4 (SFXN4) is a gene primarily associated with mitochondrial functionality and disease. It encodes a protein that is crucial for the assembly of complex I within mitochondria, a critical component of the electron transport chain. Mutations in SFXN4 can result in mitochondrial diseases due to its pivotal role in this process. Interestingly, SFXN4 belongs to the sideroflexin family, traditionally known for amino acid transport, indicating a functional evolution to support mitochondrial assembly. In the context of cancer, specifically ovarian cancer, SFXN4 is involved in the synthesis of iron-sulfur clusters (Fe-S), which are essential for cell growth and division. Inhibition of SFXN4 disrupts Fe-S biogenesis, highlighting its potential as a target for anti-cancer therapy. Additionally, SFXN4's expression and function have been correlated with immune pathways in hepatocellular carcinoma, suggesting broader implications in cancer biology. Knockdown studies and natural mutations demonstrate SFXN4's role in mitochondrial diseases, including macrocytic anemia observed in zebrafish models and implications in human mitochondriopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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