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Invitrogen
SGPL1 Polyclonal Antibody
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产品信息
PA5-90667
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment).
偶联物
形式
Liquid
浓度
1.37 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VFQPESLWSR FKKKCFKLTR KMPIIGRKIQ DKLNKTKDDI SKNMSFLKVD KEYVKALPSQ GLSSSAVLEK LKEYSSMDAF WQEGRASGTV YSGEEKLTEL LVKAYGDFAW SNPLHPDIFP GLRKIEAEIV RIACSLFNGG PDSCGCVTSG GTESILMACK AYRDLAFEKG IKTPEIVAPQ SAHAAFNKAA SYFGMKIVRV PLTKMMEVDV RAMRRAISRN TAMLVCSTPQ FPHGVIDPVP EVAKLAVKYK IPLHVDACLG GFLIVFMEKA GYPLEHPFDF RVKGVTSISA DTHKYGYAPK GSSLVLYSDK KYRNYQFFVD TDWQGGIYAS P; Positive Samples: U-87MG, LO2, 293T, A-431, Mouse liver, Mouse kidnay, Mouse lung, Rat brain ; Cellular Location: Endoplasmic reticulum membrane, Single-pass type III membrane protein
靶标信息
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ13811; hSPL; mSPL; S1PL; SP-lyase 1; sphingosine phosphate lyase 1; Sphingosine-1-phosphate aldolase; Sphingosine-1-phosphate lyase 1; SPL 1
基因别名: AI428538; D10Xrf456; KIAA1252; S1PL; SGPL1; Spgl1; SPL
UniProt ID: (Human) O95470, (Mouse) Q8R0X7, (Rat) Q8CHN6
Entrez Gene ID: (Human) 8879, (Mouse) 20397, (Rat) 286896
luteinization
vasculogenesis
kidney development
fatty acid metabolic process
ceramide metabolic process
spermatogenesis
androgen metabolic process
estrogen metabolic process
post-embryonic development
fibroblast migration
hemopoiesis
sphingolipid biosynthetic process
sphingolipid catabolic process
Leydig cell differentiation
regulation of multicellular organism growth
platelet-derived growth factor receptor signaling pathway
skeletal system morphogenesis
palate development
face morphogenesis
apoptotic signaling pathway
lipid metabolic process
sphingolipid metabolic process
nitrogen compound metabolic process
apoptotic process
female gonad development
carboxylic acid metabolic process
