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Invitrogen
SH3YL1 Polyclonal Antibody
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产品信息
PA5-56593
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FTYCKSRGLF AGVSLEGSCL IERKETNRKF YCQDIRAYDI LFGDTPRPAQ AEDLYEILDS FTEKYENEG
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
靶标信息
The SH3YL1 gene encodes a protein that contains an SH3 domain and is involved in various signaling pathways. It is particularly significant in the context of androgen receptor (AR) signaling, where it acts as a coregulator for AR target genes. Studies have shown that SH3YL1 is essential for the transcriptional activation of genes modulated by the AR, and its dysregulation is associated with aggressive prostate cancer. Additionally, elevated plasma levels of SH3YL1 have been identified as a biomarker for diabetic nephropathy, indicating its broader role in human health and disease. SH3YL1 protein expression is particularly noted in the kidneys of diabetic patients, suggesting its involvement in the development of diabetic complications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SH3 domain containing, Ysc84-like 1; SH3 domain-containing YSC84-like protein 1
基因别名: RAY; SH3YL1
UniProt ID: (Human) Q96HL8
Entrez Gene ID: (Human) 26751
