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SHANK1/SHANK3 Monoclonal Antibody (S367-51), FITC

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SHANK1/SHANK3 Monoclonal Antibody (S367-51), FITC

产品信息

200-302-W72

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化 (IHC)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

S367-51

抗原

Anti-SHANK1/SHANK3 Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 586-626 (SH3 domain) of rat SHANK3.
3D表位/免疫原

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱 spectra

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein G

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.1% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {PubMed:21606927, PubMed:21795692, PubMed:23100419, PubMed:23897824, PubMed:24089484}.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: brain specific protein; brain-specific protein; GKAP/SAPAP-interacting protein; multidomain postsynaptic density protein; postsynaptic density protein; postsynaptic scaffold protein; proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; SAPAP-interacting protein synamon; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; shank3 postsynaptic density protein; somatostatin receptor-interacting protein; SPANK-1; SPANK-2; proSAP2; proline-rich synapse-associated protein 2; SSTR-interacting protein; synamon

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基因别名: DEL22q13.3; PROSAP2; PSAP2; SCZD15; Shank1a; SPANK-1; SPANK-2; Spank1; SSTRIP; synamon

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UniProt ID: (Human) Q9Y566, (Human) Q9BYB0, (Rat) Q9WV48, (Mouse) D3YZU1, (Rat) Q9JLU4, (Mouse) Q4ACU6

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Entrez Gene ID: (Human) 50944, (Human) 85358, (Rat) 78957, (Mouse) 243961, (Rat) 59312, (Mouse) 58234

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功能
G-protein coupled receptor binding protein binding SH3 domain binding receptor signaling complex scaffold activity GKAP/Homer scaffold activity somatostatin receptor binding ionotropic glutamate receptor binding identical protein binding macromolecular complex binding ankyrin repeat binding scaffold protein binding structural constituent of postsynaptic density zinc ion binding receptor binding
参与通路
long-term memory associative learning adult behavior negative regulation of actin filament bundle assembly social behavior protein localization to synapse olfactory behavior habituation modulation of synaptic transmission synapse organization neuromuscular process controlling balance determination of affect righting reflex synapse maturation dendritic spine morphogenesis positive regulation of dendritic spine development protein-containing complex assembly vocalization behavior AMPA selective glutamate receptor signaling pathway maintenance of postsynaptic density structure positive regulation of excitatory postsynaptic potential MAPK cascade embryonic epithelial tube formation synapse assembly learning or memory learning memory locomotory behavior gene expression glial cell proliferation striatal medium spiny neuron differentiation exploration behavior locomotory exploration behavior locomotion vocal learning negative regulation of cell volume regulation of synaptic plasticity positive regulation of long-term neuronal synaptic plasticity brain morphogenesis sensory perception of touch positive regulation of synapse structural plasticity positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation long term synaptic depression regulation of dendritic spine morphogenesis neural precursor cell proliferation postsynaptic density assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering response to interleukin-17 regulation of postsynapse organization regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of glutamate receptor signaling pathway regulation of long term synaptic depression regulation of AMPA glutamate receptor clustering regulation of grooming behavior regulation of behavioral fear response cognition
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