Invitrogen

SHANK3 Monoclonal Antibody (S69)

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说明书
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说明书
实验方案
问题与答案
技术支持
SHANK3 Monoclonal Antibody (S69)

产品信息

MA5-27601

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:100
-

免疫细胞化学 (ICC/IF)

1:100
-

免疫沉淀 (IP)

Assay-Dependent
-

Antibody Microarray (AM)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

S69

抗原

Synthetic peptide amino acids 840-857 of rat Shank3
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2735363

产品详细信息

1 µg/mL of MA5-27601 was sufficient for detection of Shank3 in 10 µg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 190kDa. No cross-reactivity against Shank1 or Shank2.

靶标信息

SHANK3 is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. It interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. SHANK3 plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, SHANK3 participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. It also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. SHANK3 may be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. (Uniprot)

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; ProSAP2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; Shank3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; shank3e splice variant III; shank3e splice variant IV; SPANK 2; SPANK-2; SPANK2

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基因别名: AI841104; DEL22q13.3; Kiaa1650; PROSAP2; PSAP2; SCZD15; Shank3; Shank3b; SHANK3c-3; SHANK3c-4; SPANK-2

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UniProt ID: (Mouse) Q4ACU6, (Rat) Q9JLU4

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Entrez Gene ID: (Human) 85358, (Mouse) 58234, (Rat) 59312

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功能
actin binding protein binding protein C-terminus binding zinc ion binding SH3 domain binding GKAP/Homer scaffold activity ionotropic glutamate receptor binding identical protein binding scaffold protein binding protein self-association
参与通路
MAPK cascade embryonic epithelial tube formation synapse assembly learning memory striatal medium spiny neuron differentiation adult behavior negative regulation of actin filament bundle assembly social behavior locomotory exploration behavior vocal learning negative regulation of cell volume positive regulation of long-term neuronal synaptic plasticity brain morphogenesis neuromuscular process controlling balance protein oligomerization positive regulation of synapse structural plasticity positive regulation of synaptic transmission, glutamatergic dendritic spine morphogenesis positive regulation of dendritic spine development regulation of dendritic spine morphogenesis vocalization behavior postsynaptic density assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of glutamate receptor signaling pathway regulation of long term synaptic depression positive regulation of excitatory postsynaptic potential regulation of grooming behavior regulation of behavioral fear response positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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