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Invitrogen
SHC Polyclonal Antibody
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产品信息
PA5-79995
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human SHC (424-440aa DPSYVNVQNLDKARQAV).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human A431 whole cell, human Hela whole cell, human HepG2 whole cell, human Jurkat whole cell, rat C6 whole cell, mouse thymus tissue, mouse RAW2467 whole cell, mouse NIH3T3 whole cell. IHC: Rat Brain Tissue, Human Lung Cancer Tissue IHC-F: Rat Intestine Tissue, Rat Brain Tissue. ICC/IF: A549 Cell.
靶标信息
Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ26504; OTTHUMP00000035472; RP11-307C12.1; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; src homology 2 domain-containing transforming protein C1; Src homology 2 domain-containing-transforming protein C1
基因别名: p66; P66shc; SHC; SHC1; SHCA
UniProt ID: (Human) P29353, (Rat) Q5M824, (Mouse) P98083
Entrez Gene ID: (Human) 6464, (Rat) 85385, (Mouse) 20416
phosphotyrosine binding
transmembrane receptor protein tyrosine kinase adaptor activity
Ras guanyl-nucleotide exchange factor activity
epidermal growth factor receptor binding
insulin receptor binding
insulin-like growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
phospholipid binding
ephrin receptor binding
protein phosphatase 2A binding
protein kinase binding
receptor tyrosine kinase binding
protein complex binding
phosphoprotein binding
scaffold/adaptor protein
MAPK cascade
activation of MAPK activity
angiogenesis
response to hypoxia
epidermal growth factor receptor signaling pathway
regulation of epidermal growth factor-activated receptor activity
Ras protein signal transduction
heart development
aging
positive regulation of cell proliferation
insulin receptor signaling pathway
response to toxic substance
viral process
single organismal cell-cell adhesion
organ regeneration
neuron projection development
actin cytoskeleton reorganization
response to nicotine
IRE1-mediated unfolded protein response
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
regulation of growth
response to hydrogen peroxide
positive regulation of GTPase activity
positive regulation of DNA replication
positive regulation of vasoconstriction
positive regulation of smooth muscle cell proliferation
leukocyte migration
response to glucocorticoid
cellular response to growth factor stimulus
response to organic cyclic compound
actin cytoskeleton organization
neuron differentiation
response to insulin
cellular response to insulin stimulus
intracellular signal transduction
regulation of cell proliferation
signal transduction
