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Invitrogen
SIAH1 Polyclonal Antibody
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SIAH1 Antibody (PA5-17998) in ICC/IF
Immunocytochemistry analysis of SIAH1 using SIAH1 Polyclonal Antibody (Product # PA5-17998) in paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody.
产品信息
PA5-17998
产品规格
种属反应
Human,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (SRQTATALPTGTSKC) corresponding to the N-terminus amino acids of SIAH1 (aa 2-16).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is expected to recognize both reported isoforms (NP_003022.3; NP_001006611.1).
This antibody is predicted to react with bovine and canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
靶标信息
This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase SIAH1; FLJ08065; h HUMSIAH; hSIAH1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; Seven in absentia homolog 1; Siah-1; Siah-1a
基因别名: HUMSIAH; SIAH; SIAH1; SIAH1A
UniProt ID: (Human) Q8IUQ4, (Rat) Q920M9
Entrez Gene ID: (Human) 6477, (Rat) 140941
protein polyubiquitination
ubiquitin-dependent protein catabolic process
apoptotic process
cell cycle
spermatogenesis
nervous system development
axon guidance
anatomical structure morphogenesis
protein catabolic process
protein destabilization
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular protein metabolic process
neuron apoptotic process
positive regulation of intrinsic apoptotic signaling pathway
male meiosis I
multicellular organism development
post-embryonic development
cell differentiation
regulation of multicellular organism growth
