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Abnova
SIGLEC12 Monoclonal Antibody (1D1)
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产品信息
H00089858-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1D1
抗原
SIGLEC12 (NP_443729.1, 503 a.a. approximately 595 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: RSCRKKSARP AVGVGDTGME DANAVRGSAS QGPLIESPAD DSPPHHAPPA LATPSPEEGE IQYASLSFHK ARPQYPQEQE AIGYEYSEIN IPK
靶标信息
Sialic acid-binding immunoglobulin-like lectins are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: sialic acid binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin-like 1; Siglec; Siglec-12; Siglec-L1; SIGLEC-like 1
基因别名: S2V; Siglec-XII; SIGLEC12; SIGLECL1; SLG; UNQ9215/PRO34042
UniProt ID: (Human) Q96PQ1
Entrez Gene ID: (Human) 89858
