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Invitrogen
SIGLEC5/SIGLEC14 Monoclonal Antibody (1A5), FITC
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产品信息
MA5-28138
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1A5
抗原
Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.
靶标信息
SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD170; CD33 antigen-like 2; LLNLR-470E3.1; OB-binding protein 2; OB-BP2; Obesity-binding protein 2; sialic acid binding Ig-like lectin 14; sialic acid binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin 14; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; Siglec-14; Siglec-5
基因别名: CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5; SIGLEC14; SIGLEC5; UNQ294/PRO333
UniProt ID: (Human) Q08ET2, (Human) O15389
Entrez Gene ID: (Human) 100049587, (Human) 8778
