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A suggested positive control is SW480 cell lysate.
PA5-34339 can be used with blocking peptide PEP-1254.
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Qin-induced kinase; salt induceable kinase 2; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2
基因别名: G630080D20Rik; KIAA0781; LOH11CR1I; QIK; RGD1559698; SIK-2; SIK2; SNF1LK2
UniProt ID: (Human) A8K5B8, (Mouse) Q8CFH6
Entrez Gene ID: (Human) 23235, (Mouse) 235344, (Rat) 315649