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SIRP alpha/beta Monoclonal Antibody (SE5A5), APC
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产品信息
MA574220
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
SE5A5
抗原
NIH-3T3 / human CD172a cell line.
偶联物
APC
APC
APC
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
SIRP alpha/beta (SIRP alpha/beta) are closely related receptors expressed on myeloid cells that help regulate innate immune responses. SIRP alpha (CD172a) is an inhibitory receptor that binds CD47 and suppresses phagocytosis via ITIM-mediated signaling, while SIRP beta lacks ITIMs and instead signals through adaptor proteins like DAP12 to promote activation and inflammation. Together, they function as a paired system that balances inhibitory and activating signals in immune regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bit; Brain Ig-like molecule with tyrosine-based activation motifs; CD172 antigen-like family member A; CD172 antigen-like family member B; CD172a; CD172b; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; p84; SHP substrate 1; Signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; Signal-regulatory protein beta-1; Signal-regulatory protein beta-1 isoform 3; Sirp-alpha-1; Sirp-alpha-2; Sirp-alpha-3; SIRP-beta-1; SIRP-beta-1 isoform 3; SIRPA/SIRPB; Tyrosine-protein phosphatase non-receptor type substrate 1
基因别名: BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; SIRPA; SIRPB1
Entrez Gene ID: (Human) 140885, (Human) 10326
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